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KMID : 0388220070140020118
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Journal of the Korean Rheumatism Association
2007 Volume.14 No. 2 p.118 ~ p.124
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The Expression of Toll-like Receptors in Idiopathic Inflammatory Myopathies
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Kim Gun-Tae
Lee Sun-Hee
Kim Dae-Seong
Lee Jun-Hee
Back Seung-Hoon
Lee Joung-Wook
Cho Mi-La
Kim Seong-Il
Kim Joo-In
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Abstract
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Objective: To investigate the expression of toll-like receptor (TLR)-2, 4 and 9 in idiopathic inflammatory myopathies (IIMs).
Methods: The expression of TLR-2, 4 and 9 was measured by real-time RT-PCR and immunohistochemical stain (IHS) from muscle tissues in patients with IIMs and controls.
Results: The expression levels of TLR-2, 4 and 9 in IIMs were significantly higher than controls. TLR-2, 4 and 9 were mainly expressed on sarcolemma of muscle fibers, perimysial vascular endothelium and infiltrating inflammatory cells in dermatomyositis, whereas, they were mainly expressed on sarcolemma of muscle fibers, destructed muscle fibers, and enodmysial infiltrating inflammatory cells in polymyositis.
Conclusion: TLR-2, 4 and 9 were highly expressed in muscle tissue of IIMs. These results suggest that TLR-2, 4 and 9 play a role in pathogenesis of IIMs.
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KEYWORD
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Toll-like receptors, Idiopathic inflammatory myopathy
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